Buy Lotrel (Amlodipine, Benazepril) online

Buy Lotrel (Amlodipine Besylate, Benazepril HCl) antihypertensive drug
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LOTREL (AMLODIPINE, BENAZEPRIL): CLINICAL STUDIES

Over 950 patients received Amlodipine Besylate, Benazepril Hydrochloride (Lotrel) once daily in six double-blind, placebo-controlled studies. The antihypertensive effect of a single dose persisted for 24 hours, with peak reductions achieved 2-8 hours after dosing.

Once-daily doses of benazepril / amlodipine using benazepril doses of 10-20 mg and amlodipine doses of 2.5-10 mg decreased seated pressure (systolic/diastolic) 24 hours after dosing by about 10-25/6-13 mmHg.

In two studies in patients not adequately controlled on either benazepril 40 mg alone (n=329) or amlodipine 10 mg alone (n=812) once daily doses of Lotrel 10/40 mg further decreased seated blood pressure compared to the respective monotherapy alone.

Combination therapy was effective in blacks and nonblacks. Both components contributed to the antihypertensive efficacy in nonblacks, but virtually all of the antihypertensive effect in blacks could be attributed to the amlodipine component. Among nonblack patients in placebo-controlled trials comparing Lotrel to the individual components, the blood pressure lowering effects of the combination were shown to be additive and in some cases synergistic.

During chronic therapy with Amlodipine Besylate, Benazepril HCl (Lotrel), the maximum reduction in blood pressure with any given dose is generally achieved after 1-2 weeks. The antihypertensive effects of Lotrel have continued during therapy for at least 1 year. Abrupt withdrawal of Lotrel has not been associated with a rapid increase in blood pressure.


Lotrel (Amlodipine, Benazepril) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Benazepril Preferred Distributors - Benazepril Hydrochloride
  • Tablets, Film-Coated; Oral; Benazepril Hydrochloride 5 mg
  • Tablets, Film-Coated; Oral; Benazepril Hydrochloride 10 mg
  • Tablets, Film-Coated; Oral; Benazepril Hydrochloride 20 mg
  • Tablets, Film-Coated; Oral; Benazepril Hydrochloride 40 mg
  • Preferred Distributors
  • Captohexal Cor - Captopril
  • Tablets; Oral; Captopril 12.5 mg
  • Novartis
  • Hexal
  • Sandoz


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