Buy Lotrel (Amlodipine Besylate, Benazepril HCl) antihypertensive drug
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LOTREL (AMLODIPINE, BENAZEPRIL): DOSAGE AND ADMINISTRATION
Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5-10 mg while benazepril is effective in doses of 10-80 mg. In clinical trials of amlodipine / benazepril combination therapy using amlodipine doses of 2.5-10 mg and benazepril doses of 10-40 mg, the antihypertensive effects increased with increasing dose of amlodipine in all patient groups, and the effects increased with increasing dose of benazepril in nonblack groups.
The antihypertensive effect of Lotrel (Amlodipine / Benazepril) is largely attained within 2 weeks.
It is usually appropriate to begin therapy with Lotrel only after a patient has either failed to achieve the desired antihypertensive effect with one or the other monotherapy, or demonstrated inability to achieve adequate antihypertensive effect with amlodipine therapy without developing edema.
Regimens of therapy with Lotrel (Amlodipine with Benazepril) need not take account of renal function as long as the patient's creatinine clearance is > 30 ml / min / 1.73m2 (serum creatinine roughly <= 3 mg / dl or 265 mmol / l). Lotrel is not recommended in patients with more severe renal impairment.
Hepatic Impairment and Elderly Patients
The recommended initial dose of amlodipine, as monotherapy or as a component of combination therapy, is 2.5 mg.
A patient whose blood pressure is not adequately controlled with amlodipine (or another dihydropyridine) alone or with benazepril (or another ACE inhibitor) alone may be switched to combination therapy with Lotrel.
In patients whose blood pressure is adequately controlled with amlodipine but who experience unacceptable edema, combination therapy may achieve similar (or better) blood pressure control with less edema.
Lotrel (Amlodipine Besylate, Benazepril Hydrochloride) may be substituted for the titrated components.
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Lotrel prescribing information
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